Including Solanum lycopersicum, there are currently 13 species recognized in Solanum section Lycopersicon. Three of these species — S. cheesmaniae, galapagense, and pimpinellifolium — are fully cross compatible with domestic tomato. Four more species—S. chmielewskii, S. habrochaites, S. neorickii, and S. pennelli—can be readily crossed with domestic tomato, with some limitations. Five species—S. arcanum, S. chilense, S. corneliomulleri, S. huaylasense, and S. peruvianum—can be crossed with domestic tomato with difficulty and usually require embryo rescue to produce viable plants. The Lycopersicon section has not been fully sampled within wild species in the South American range, so new species may be added in the future.

Solanum section Lycopersicoides and section Juglandifolium are represented by two species each that are considered bridge species genetically intermediate between tomato and non-tuber bearing potato species. S. lycopersicoides can be crossed with domestic tomato and introgression lines[17] have been developed. This species was significant in moving the domestic tomato from separate genus status into the Solanum group because it directly links the tomato into the potato family.